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叶加

叶加,女,博士,博士后,教授。1993年上海中医药大学获医学博士学位,1993-1995北京医科大学基础医学院从事分子生物学博士后研究工作。1995-1996中国医学科学院基础医学研究所医学分子生物学国家重点实验室进行分子免疫学研究。1997获日本长寿振兴财团基金,在WHO日本东京都老人综合研究所从事免疫研究工作,寻找类风湿性关节炎病理基因,探讨免疫耐受与自身免疫病发病机制的关系。近年主要从事神经免疫药理学、中药药理学的研究。主编和参编药理学、中药学相关着作10部。主持和参加国家自然科学基金、北京市自然科学基金、国家“973”十一五等科研项目。在国际上首次发现体内镇痛抗炎新靶点---外周a7nAChR/M4AChR,及相关信号通路。激活a7nAChRM4AChR可引起较强的镇痛抗炎作用而无明显毒副作用。近年以责任作者发表国外SCI和国内核心杂志科研论文30余篇,申请及授权世界专利3项和中国专利8项。

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研究方向

中药药理,免疫药理,镇痛抗炎药理。

研究课题

1. 以外周a7nAChR为靶的镇痛抗炎药物研究

2. 活化a7nAChR/M4AchR后镇痛抗炎相关信号通路研究

3. 抗移植排斥药物及机制研究

4. 中药镇痛抗炎机制研究

5. 中药药性理论继承与创新研究

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近年发表代表性论文

1.????? Dan Wan, Ding Wang, Qi Sun, Yan Song, YiMin Jiang, RunTao Li, Jia Ye*. Antinociception of spirocyclopiperazinium salt compound LXM-10-M targeting a7 nicotinic receptor and M4 muscarinic recaptor and inhibiting CaMKIIa/CREB/CGRP signaling pathway in mice.European Journal of Pharmacology ?2016, 770: 92–98 (IF 2.754)

2.????? Xiaoli Gao, Hua Yang,Yangguang Xu,Yulan Xiong, Guannan Wang, Xinshan Ye, Jia Ye* Iminosugar derivative WGN-26 suppresses acute allograft rejection via inhibiting the IFN-γ/p-STAT1/T-bet signaling pathway. International Immunopharmacology 2014, 23: 688-695 (IF 2.722)?

3.????? Weiwei Zhang, Qi Sun, Xiaoli Gao, Yimin Jiang, Runtao Li, Jia Ye*Anti-Inflammation of Spirocyclopiperazinium Salt Compound LXM-10 Targeting a7 nAChR and M4 mAChR and Inhibiting JAK2/STAT3 Pathway in Rats. PLOS ONE ?2013, 8(6):1-8 (8: e66895) (IF 4.015)

4.????? Xia Zhao, Jia Ye*, Qi Sun, Yulan Xiong, Runtao Li and Yimin Jiang Antinociceptive effect of spirocyclopiperazinium salt compound LXM-15 via activating peripheral α7 nAChR and M4 mAChR in mice. Neuropharmacology 2011, 60:446-452?? (IF 5.106)

5.????? Song-Wen Lin, Qi Sun, Ze-Mei Ge, Xin Wang, Jia Ye*, Run-Tao Li*?Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ). Bioorganic & Medicinal Chemistry Letters2011, 21: 940–943 ( IF 2.447)?

6.????? Yulan Xiong, Xia Zhao, Qi Sun, Runtao Li, Changling Li, Jia Ye*Antinociceptive mechanism of the spirocyclopiperazinium compound LXM-10 in mice and rats.??? ????Pharmacol. Biochem. Behav.2010, 95:192–197 (IF2.772)?

7.????? Yulan Xiong, Jia Ye*, Qi Sun, Xia Zhao, Runtao Li, Yimin Jiang, Anti-inflammatory effect of the spirocyclopiperazinium compound LXM-10 in mice and rats. ?European Journal of Pharmacology2010, 626: 290–296 (IF 2.754) ?

8.????? Guo-Liang Zhang, Changshui Chen, Yulan Xiong, Jia Ye*Xin-Shan Ye*Synthesis of N-substituted iminosugar derivatives and their immunosuppressive activities. Carbohydrate Research 2010, 345: 780–786 (IF 2.148)

9.????? Deng-Bo Ji,Jia Ye*, Chang-Ling Li, Yu-Hua Wang, Jiong Zhao and Shao-Qing Cai? Antiaging Effect of Cordyceps sinensis Extract. Phytotherapy Research 2009, 23:116–122 (IF2.48)

10.?? 10. Deng-Bo Ji, Jia Ye*, Yi-Min Jiang and Bo-Wen Qian?? Anti-tumor effect of Liqi, a traditional Chinese medicine prescription, in tumor bearing mice. BMC Complementary and Alternative Medicine2009, 9:20(IF 2.343)?

11.?? Deng Bo Ji, Chang Ling Li, Jia Ye*, Hai Bo Zhu*? Effect of Hydroxysafflor yellow A on Human Umbilical Vein Endothelial Cells under hypoxia. Vascular Pharmacology 2009, 50: 137–145 (IF 3.134)

12.?? Ji DB, Zhu MC, Zhu B, Zhu YZ, Li CL,Ye J*, Zhu HB*,? Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1 alpha-VEGF pathway and regulation of Bcl-2/Bax. J Cardiovasc Pharmacol 2008, 52 (2) :191-202 (IF2.243)

13.?? Deng Bo JI, Hai Bo ZHU, Jia YE*, Chang Ling LI* ?Establishment of a Cell-Based Assay to Screen Regulators of the Hypoxia-Inducible Factor-1-Dependent Vascular Endothelial Growth Factor promoter. Biol. Pharm. Bull. 2008, 31(12): 2255–2259 (IF 1.904)?

14.?? Cai-Qin Yue, Jia Ye*, Chang-Ling Li, Run-Tao Li, Qi Sun. ?Antinociceptive effects of the novel spirocyclopiperazinium salt compound LXM -10 in mice. Pharmacol. Biochem. Behav.?2007, 86:643–650.(IF 2.772)